This dataset provides annual statistical descriptors: mean, minimum, maximum, range and standard deviation(std.dev) of key biogeochemical and physical variables for the Mediterranean Sea. It covers the period 2005-2099 under the RCP8.5 scenario, with a spatial resolution of 1/24 degree (~4km²). Variables include temperature, salinity, pH, water velocity, nutrients (NO3, PO4, NH4), dissolved inorganic carbon, oxygen, and net primary production. Data are available for both surface and at bathymetry level. The original projections were generated using OGSTM-BFM and MFS16 models at daily time and 1/16 degree grid resolution. We downscaled these to 1/24 degree and applied Quantile Delta Mapping bias correction using CMEMS reanalysis products for 2005-2020. The dataset is composed of 95 files in a single folder. Names are structured as ‘{statistical_indicator}{varname}{layer}.nc’ (e.g. mean_thetao_bottom.nc). Note that for Net Primary Production, there are layers reporting the vertical integration of 0-220m depth layers named ‘{statistical_indicator}_{nppv}_integrated.nc’. a complete list of the files is added as resource.